Pentachlorphenol as an Uncoupler for Oxidative Phosphorylation
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چکیده
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Crystal violet as an uncoupler of oxidative phosphorylation in rat liver mitochondria.
Crystal violet exhibited characteristics of an uncoupler of oxidative phosphorylation, i.e. it released respiratory control, hindered ATP synthesis, enhanced ATPase activity, and produced swelling of isolated rat liver mitochondria. Maximal stimulation of respiration, ATPase activity, and swelling was observed at a concentration of 40 microM. The inhibition of State 3 respiration by oligomycin ...
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متن کاملAdaptation of Escherichia coli to the uncoupler of oxidative phosphorylation 2,4-dinitrophenol.
Escherichia coli was found to adapt to the uncoupler of oxidative phosphorylation 2,4-dinitrophenol. The rates of synthesis of 53 proteins were increased following exposure to 2,4-dinitrophenol. Adaptation was accelerated when the cofactor pyrroloquinoline quinone was provided in the growth medium.
متن کاملThe cyanine dye triS-C4(5) as a cationic uncoupler of oxidative phosphorylation: interaction with mitochondria detected by derivative spectrophotometry.
Derivative spectrophotometry was used to study the interaction of the cationic uncoupler triS-C4(5) with mitochondria. The uncoupling action of this dye is dependent on the presence of Pi in the incubation medium. The second derivative spectrum of the dye changed with the incubation period, becoming similar to the spectrum in chloroform; but, after a time, the spectral pattern reverted to the o...
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ژورنال
عنوان ژورنال: Sangyo Igaku
سال: 1965
ISSN: 0047-1879,1881-1302
DOI: 10.1539/joh1959.7.4_256_3